Assessment of Pharmaco-Technological Parameters of Solid Lipid Nanoparticles as Carriers for Sinapic Acid

Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim this work was incorporate sinapic acid into solid lipid nanoparticles in order improve its bioavailability. SLNs were prepared using hot high-speed homogenization method. pharmaco-technological properties thermotropic profile encapsulated with as well their interaction biomembrane models, evaluated. showed promising physicochemical encapsulation efficiency, a desirable release profile; moreover, they facilitated model made multilamellar vesicles. In conclusion, formulation can be used further studies assess suitability